A CURE FOR SPINAL CORD INJURY IN THE PROCESS OF CLINICAL TRIAL
Many physicians and scientists devote their lives to this goal. There have been many promising advancements in research into spinal cord injury recently. It is hoped that these advancements will lead to a cure.
The following discoveries are leading the world now:
Scientists solved the key problem of central nerve regeneration that is the neuron regeneration for the first time in the world.
NT3-chitosan elicits robust endogenous neurogenesis to enable functional recovery after spinal cord injury
https://www.pnas.org/content/112/43/13354 October 12, 2015
Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury
https://www.pnas.org/content/112/43/13360 October 12, 2015
On repairing spinal cord injury of higher primate rhesus monkeys. For the repaired adult rhesus monkey, the cortical spinal tract (CST) regeneration distance is up to 15 mm, the longest one in the world. Since rhesus monkeys are very similar to humans, it brings greater hope for the clinical cure of patients with spinal cord injury.
NT3-chitosan enables de novo regeneration and functional recovery in monkeys after spinal cord injury
https://www.pnas.org/content/115/24/E5595 May 29，2018
It has been verified by an independent third-party verification experiment by the Miami Paraplegic Repair Program.
Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord
Exp Neurol. 2019 Feb;312:51-62. doi: 10.1016/j.expneurol.2018.11.003. Epub 2018 Nov 22.
Professor Frank Bradke, academician of the German Academy of Sciences, gave a highly praised article.
Reproducibility - The key towards clinical implementation of spinal cord injury treatments?
Exp Neurol. 2019 Mar;313:135-136. doi: 10.1016/j.expneurol.2018.12.010. Epub 2018 Dec 31.
Acta Biomaterialia Functional hyaluronate collagen scaffolds induce NSCs differentiation into functional neurons in repairing the traumatic brain injury
Biomaterials Neural repair by NT3-chitosan via enhancement of endogenous neurogenesis after adult focal aspiration brain injury
Experimental Neurology Reproducibility – The key towards clinical implementation of spinal cord injury treatments
Since the central nervous system (brain and spinal cord) can not regenerate. The "brain-computer interface" can only indirectly exercise muscles. The "newborn neural network" is a real neural reconstruction, which the feelings and movements formed are truly precise behaviors!